Pancreatic Beta-cell growth and diabetes mellitus
نویسندگان
چکیده
منابع مشابه
Pancreatic Islet Beta-Cell Apoptosis in Experimental Diabetes Mellitus
For screening and detailed studying of antidiabetic medications, various genetic and nongenetic experimental models of diabetes mellitus were used (Islam S., Loots D.T. 2009). And though they are not absolutely equivalent to etiopathogenetic mechanisms of human pathological conditions, each of them represents itself as an integral tool for research into genetic, endocrine, metabolic, morphologi...
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Diabetes with a broad spectrum of complications has become a global epidemic metabolic disorder. Till now, several pharmaceutical and non-pharmaceutical therapeutic approaches were applied for its treatment. Cell-based therapies have become promising methods for diabetes treatment. Better understanding of diabetes pathogenesis and identification of its specific biomarkers along with evaluation ...
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During pregnancy, maternal pancreatic islets grow to match dynamic physiological demands, but the mechanisms regulating adaptive islet growth in this setting are poorly understood. Here we show that menin, a protein previously characterized as an endocrine tumor suppressor and transcriptional regulator, controls islet growth in pregnant mice. Pregnancy stimulated proliferation of maternal pancr...
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During the past 30 years great effort has been put into establishing an insulin-secreting beta cell line that retains normal regulation of insulin secretion, but only few of these attempts have been successful. To overcome the limited availability of primary beta cells and to include the principles of the 3Rs into the field of diabetes mellitus research, numerous investigators used X-rays or vi...
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It will be discussed here the use of the systems biology approach to understand complex human diseases, taking as an example type 1 diabetes mellitus (T1DM). In the course of this discussion, a definition of the systems biology approach will be presented and its potential impact on the 3Rs commented. Type 1 diabetes mellitus (T1DM) is one of the most prevalent chronic diseases in children and a...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1992
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00400917